1. in issue在争论中，在争议中
The problem is still in issue.
这个问题仍在争议之中。
例外，issue还有“期刊”之意，如：
The article appeared in issue 25.
该文发表在第25期。《牛津高阶英汉双解词典》
in issue相当于at issue争论中的;讨论中的
One of the main points at issue is that the Community wants the representatives to be based in East Jerusalem.
争论的要点之一是，共同体希望代表们的总部设在东耶路撒冷。
The problems of immigration were not the question at issue
移民问题不在讨论之列。
Her ability is not at issue, it's her character I'm worried about.
她的能力毫无争议，我担心的是她的人品。
2.in the issue结果，最终
They came to the same in the issue.
结果它们却是同一回事。
The problem hasn’t been settled in the issue.
这个问题最终也未得到解决。