1. in issue 在争论中，在争议中
The problem is still in issue.
这个问题仍在争议之中。
in issue相当于at issue争论中的;讨论中的
One of the main points at issue is that the Community wants the representatives to be based in East Jerusalem.
争论的要点之一是，共同体希望代表们的总部设在东耶路撒冷。
The problems of immigration were not the question at issue
移民问题不在讨论之列。
Her ability is not at issue, it's her character I'm worried about.
她的能力毫无争议，我担心的是她的人品。
2.in the issue结果，最终
They came to the same in the issue.
结果它们却是同一回事。
The problem hasn’t been settled in the issue.
这个问题最终也未得到解决。
其它用法总结
1 名词 “issue” 可以表示 “议题，重要话题”。
She usually writes about environmental issues.
她通常写环境方面的题材。
The environment has become a very hot issue.
环境已成为很热门的话题。
All the parties pay lip service to environmental issues.
对环境问题，各方都是口惠而实不至。
The energy crisis is a big issue for many people.
能源危机对许多人来说是个重要话题。
2 名词 “issue” 可以表示 “问题、异议、争端”，与 “problem” 意思相近。
a key/sensitive/controversial issue
关键的 / 敏感的 / 有争议的问题
The president appears likely to change course on some key issues.
总统看起来可能要在某些重要问题上改变方针。
This book deals with the social, economic and political issues of the period.
这本书论及了那个时期的社会、经济和政治问题。
Careful consideration should be given to issues of health and safety.
健康与安全的问题应该认真予以考虑。
If you have any issues, please call this number.
如有问题，请拨打这个电话号码。
You can look at the issue from many different angles.
你可以从很多不同的角度看这个问题。
There are three main issues that we need to direct our attention to.
我们需要注意的主要有三个问题。
The union plans to raise the issue of overtime.
工会打算提出加班的问题。
The party was divided on this issue.
该党在这一问题上存在分歧。
She's always on a diet ─ she has issues about food.
她经常节食——她担心吃得太多。
Agents will raise the issue of prize-money for next year's world championships.
经纪人将提出下年度世锦赛奖金的问题。
You're just avoiding the issue .
你只不过是在回避问题。
The government is divided on this issue.
政府在这个问题上意见不统一。
have issues with在…方面有困难
I think once you do have issues with food you're going to have them for the rest of your life.
我认为一旦你吃东西有问题的话,你可能终生都会如此。
He still has some issues with women.
他在与女性打交道方面仍有些问题。
make an issue of使…引起关注;在…上挑起争论
It seemed the Colonel had no desire to make an issue of the affair.
看上去上校不想在那件事上挑起争端。
This isn't very important ─ I don't want to make an issue of it.
这不太重要——我不想把它当回事儿。
take issue with不同意;对…持异议
Sister Morrison might take issue with me on that matter...
莫里森修女在那件事上或许会和我持不同意见。
I've got issues with my neighbour over parking.
我和邻居在停车问题上有意见。
take issue with sb (about/on/over sth)
向某人提出异议；开始与某人争论
I must take issue with you on that point.
我必须就那一点向你提出异议。
3 动词 “issue” 可以表示 “发表;发布；发出，颁发（正式文件）”。
Last night he issued a statement denying the allegations.
昨晚他发表声明否认那些指控。
On your appointment you will be issued with a written statement of particulars of employment.
正式任命时,你会拿到一份关于雇用细则的书面声明。
I'm waiting for reception to issue my work pass.
我正在等待前台为我发放工作通行证。
My new driving licence has finally been issued.
我的新驾照终于颁发了。
4 名词 “issue” 还可以表示同一报刊杂志的 “版次、期、号”。
This is today's issue. Get today's issue now.
She will be on the front cover in the next issue of this fashion magazine.
The article appeared in issue 25.
该文发表在第25期。